The World Congress on Alternatives and Animal Use in the Life Sciences (WC series) was established by the Alternatives Congress Trust in Baltimore, USA in 1993 to bring together multidisciplinary stakeholders from academia, industry, government, and non-profit sectors under one roof to advance the 3Rs—to reduce, refine, and replace the use of animals in the life sciences. Since 1993, the WC series has been held biennially or triennially across the continents from the Americas to Europe and the Far East. This iconic series is coming back to the True North in 2023! We gratefully acknowledge that WC12 will be held in Niagara Falls, on the Traditional Territory of the Anishinaabe and the Haudenosaunee Peoples of Canada.